Polymyxin B sulfate ( Aerosporin; Mastimyxin )

Catalog No. M11699 CAS No. 1405-20-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Polymyxin B sulfate
Note

Research use only, not for human use.
Brief Description

Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains.
Description

Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
Synonyms

Aerosporin; Mastimyxin
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Infection
Indication

——

CAS Number

1405-20-5
Formula Weight

1301.56
Molecular Formula

C56H100N16O17S
Purity

>98%(HPLC)
Solubility

Water: 25 mg/mL
SMILES

CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
Chemical Name

N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid

1.Severino P, et al. Colloids Surf B Biointerfaces. 2015 May 1;129:191-7.

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